Issues Notice

Prof. Sang Hyun Ahn

Overview

The interplay between vascular dysfunction, metabolic dysregulation, and tumor microenvironmental remodeling represents a unifying framework underlying many major human diseases. From acute coronary syndromes and cardiometabolic disorders to cancer progression driven by stromal–vascular crosstalk, shared biological pathways govern inflammation, endothelial injury, fibrosis, angiogenesis, and cellular stress responses.

This Special Issue of Health Research and Practice (HRP) aims to present an integrated perspective on translational disease mechanisms, highlighting how vascular biology, metabolic disorders, and tumor-associated stromal dynamics converge to influence disease progression and therapeutic outcomes. We welcome contributions that bridge basic mechanisms with preclinical or clinical applications, leveraging emerging technologies such as organoids, AI-driven analytics, and localized or targeted therapeutic strategies.

Topics of Interest

We invite original research articles, reviews, and short communications on the following topics (but not limited to):

Vascular Injury & Cardiovascular Disease

• Endothelial dysfunction and vascular inflammation
• Acute coronary syndromes, PCI advancements, and imaging-guided interventions
• Thrombosis, plaque instability, and ischemia–reperfusion injury

Tumor Microenvironment & Stromal–Vascular Interactions

• CAF biology, periostin-driven pathways, stromal biomarkers
• Tumor angiogenesis, vascular-targeted therapies, and local drug delivery
• Stromal–immune–vascular crosstalk in solid tumors

Metabolic Disorders & Organ Modeling

• Mechanisms of MAFLD, steatosis, mitochondrial dysfunction, and fibrosis
• Human liver organoids for metabolic disease modeling
• CRISPR, multi-omics, and AI-based drug discovery platforms

Translational Therapeutics & Interventional Advances

• Localized vascular-targeted delivery (TAE, TACE, EUS-FNI)
• Novel small molecules, biologics, and immunometabolic therapies
• Precision medicine and patient-derived disease models

Systems-Level Approaches

• AI-based diagnostics and biomarker prediction
• Multi-omics integration for disease stratification
• Cross-disease comparisons of shared vascular and metabolic pathways

Submission Guidelines

Submission Deadline: November 21, 2025

Please submit your manuscript through the HRP online submission system.

All manuscripts will undergo single-blind peer review.

Article types accepted: Original Articles, Review Articles, Short Communications

Submitted manuscripts must be original and not under consideration elsewhere.

Accepted papers will be published promptly online and featured in this Special Issue.

 Why contribution?

Opportunity to publish in a peer-reviewed, international open-access journal

Reach a global audience in public health, clinical medicine, and translational science

Benefit from rapid publication and dedicated editorial support

APC discounts or waivers may be available for selected authors.

📩 Contact the Director Editor

For inquiries or to express interest in contributing to this Special Issue,

 please contact: [info@ghrn-hub.org]